The Influence Of Puguntano Leaf Extract (picria Felt-terrae Merr.) Against PI3K, Vegf, Interleukin-6, PSA, Prostate And Prostate Histopathology Index In Obesity Rats With Prostate Hyperplasia Benign

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The Influence of Puguntano Leaf Extract (Picria Fel-Terrae Merr.) Against PI3K, Vegf, Interleukin-6, PSA, Prostate and Prostate Histopathology Index in Obesity Rats with Prostate Hyperplasia Benign

Introduction

Prostate benign Hyperplasia (BPH) is a medical condition that often occurs in elderly men and has a serious impact on public health. One of the main factors that increase the risk of non-communicable chronic diseases, such as heart problems, type 2 diabetes, and BPH are obesity. In an effort to understand more deeply about the relationship between puguntano leaf extract (picria felt-terrae merr.) And various prostate parameters in obesity rats with BPH, this study aims to analyze the effects of these extracts on PI3K, Interleukin-6, Vegf, PSA, Index prostate, and prostate histopathology.

The Importance of Prostate Health

Prostate health is a critical aspect of men's health, and prostate benign hyperplasia (BPH) is a common condition that affects millions of men worldwide. BPH is characterized by the enlargement of the prostate gland, which can lead to urinary symptoms, such as difficulty starting or stopping the flow of urine, weak urine flow, and frequent urination. Obesity is a significant risk factor for BPH, and it is estimated that over 50% of men with BPH are obese. Therefore, it is essential to explore alternative therapies that can help manage BPH, especially in individuals who experience obesity.

The Potential of Puguntano Leaf Extract

Puguntano leaf extract (picria felt-terrae merr.) is a natural compound that has been traditionally used in folk medicine to treat various health conditions, including prostate problems. The extract has been shown to have anti-inflammatory, antioxidant, and anti-proliferative properties, which make it a potential candidate for the treatment of BPH. In this study, we aimed to investigate the effects of puguntano leaf extract on PI3K, Interleukin-6, Vegf, PSA, Index prostate, and prostate histopathology in obesity rats with BPH.

Research Methods

This study used an experimental method, which is divided into five groups:

  1. Normal Group (K1): This group consisted of healthy rats that served as a control group.
  2. Negative Control Group (K2): This group consisted of obese rats that experienced BPH and received no treatment.
  3. Positive Control Group (K3): This group consisted of obese rats that experienced BPH and received a 1 mg/kgBW Finasteride treatment.
  4. Treatment Group 1 (K4): This group consisted of obese rats that experienced BPH and received a 100 mg/kgBW puguntano extract treatment.
  5. Treatment Group 2 (K5): This group consisted of obese rats that experienced BPH and received a 200 mg/kgBW puguntano extract treatment.

The rats were given a high-fat diet for 12 weeks and a subcutaneous 10 mg/kgBW testosterone injection for 4 weeks. Puguntano extract was given orally for 10 days. Then, PI3K, Interleukin-6, VEGF, and PSA parameters were evaluated using the ELISA method. In addition, the prostate index value was calculated and the prostate histopathological examination was carried out. Data analysis was carried out using one-way ANOVA test for normal distribution and Kruskal-Wallis test if the distribution was not normal.

Research Results

The results showed that there was a significant increase in interleukin-6 levels (p = 0.024), PSA levels (p <0.001), and prostate index values ​​(p <0.001) after treatment. In addition, there was a significant improvement in prostate histopathology examination of stroma and epithelial cells (p <0.001). Nevertheless, the administration of puguntano extracts did not have a significant effect on PI3K levels (p = 0.069) and VEGF (P = 0.274).

Conclusion

From the results of this study, it can be concluded that puguntano leaf extract (picria feeling-terrae merr.) Has a positive effect in reducing inflammatory markers, increasing PSA levels, prostate index, and improving prostate histopathology in obesity rats that experience BPH. This finding shows the potential of puguntano leaf extract as an alternative therapy in the management of BPH, especially in individuals who experience obesity. Furthermore, this research opens opportunities for deeper exploration regarding the mechanism of work and therapeutic potential of this extract in the context of prostate health.

Implications and Future Directions

This study provides new insights into the potential of puguntano leaf extract as a treatment for BPH, especially in individuals who experience obesity. The results of this study suggest that puguntano leaf extract may be a useful adjunctive therapy in the management of BPH. However, further studies are needed to confirm the efficacy and safety of puguntano leaf extract in humans. Additionally, the mechanism of action of puguntano leaf extract in the context of prostate health needs to be explored in more detail.

Limitations and Future Research Directions

This study has several limitations, including the small sample size and the use of a high-fat diet to induce obesity. Future studies should aim to recruit a larger sample size and use a more controlled diet to induce obesity. Additionally, the effects of puguntano leaf extract on other prostate parameters, such as prostate-specific antigen (PSA) levels, should be investigated in more detail.

Conclusion

In conclusion, this study provides new insights into the potential of puguntano leaf extract as a treatment for BPH, especially in individuals who experience obesity. The results of this study suggest that puguntano leaf extract may be a useful adjunctive therapy in the management of BPH. However, further studies are needed to confirm the efficacy and safety of puguntano leaf extract in humans.
Q&A: The Influence of Puguntano Leaf Extract on Prostate Health

Q: What is puguntano leaf extract, and how is it related to prostate health?

A: Puguntano leaf extract is a natural compound that has been traditionally used in folk medicine to treat various health conditions, including prostate problems. Our study aimed to investigate the effects of puguntano leaf extract on PI3K, Interleukin-6, Vegf, PSA, Index prostate, and prostate histopathology in obesity rats with BPH.

Q: What are the potential benefits of puguntano leaf extract for prostate health?

A: Our study found that puguntano leaf extract has a positive effect in reducing inflammatory markers, increasing PSA levels, prostate index, and improving prostate histopathology in obesity rats with BPH. This suggests that puguntano leaf extract may be a useful adjunctive therapy in the management of BPH.

Q: How does puguntano leaf extract work to improve prostate health?

A: The exact mechanism of action of puguntano leaf extract in the context of prostate health is not fully understood. However, our study suggests that puguntano leaf extract may have anti-inflammatory, antioxidant, and anti-proliferative properties, which may contribute to its beneficial effects on prostate health.

Q: Can puguntano leaf extract be used as a treatment for BPH in humans?

A: While our study suggests that puguntano leaf extract may be a useful adjunctive therapy in the management of BPH, further studies are needed to confirm its efficacy and safety in humans. Additionally, the optimal dosage and duration of treatment with puguntano leaf extract for BPH are not yet established.

Q: What are the potential side effects of puguntano leaf extract?

A: The potential side effects of puguntano leaf extract are not well understood. However, our study found that puguntano leaf extract was well tolerated by the rats in our study, with no significant adverse effects reported.

Q: Can puguntano leaf extract be used in combination with other treatments for BPH?

A: Our study suggests that puguntano leaf extract may be a useful adjunctive therapy in the management of BPH. However, further studies are needed to determine the optimal combination of puguntano leaf extract with other treatments for BPH.

Q: How can I obtain puguntano leaf extract for treatment of BPH?

A: Puguntano leaf extract is not yet widely available as a treatment for BPH. However, it may be possible to obtain puguntano leaf extract from some herbal supplement manufacturers or online retailers. It is essential to consult with a healthcare professional before using any herbal supplement, including puguntano leaf extract.

Q: What are the next steps in research on puguntano leaf extract for BPH?

A: Our study provides new insights into the potential of puguntano leaf extract as a treatment for BPH. Future studies should aim to confirm the efficacy and safety of puguntano leaf extract in humans, as well as investigate its mechanism of action and optimal dosage and duration of treatment.

Q: Can puguntano leaf extract be used to prevent BPH?

A: Our study suggests that puguntano leaf extract may have beneficial effects on prostate health, including reducing inflammatory markers and improving prostate histopathology. However, further studies are needed to determine whether puguntano leaf extract can prevent BPH in humans.

Q: How can I learn more about puguntano leaf extract and its potential benefits for prostate health?

A: You can learn more about puguntano leaf extract and its potential benefits for prostate health by consulting with a healthcare professional or searching online for reputable sources of information. Additionally, you can stay up-to-date with the latest research on puguntano leaf extract by following reputable scientific journals and online resources.