The Association Between The Administration Of Ophiocephalus Striatus Extract To Carnosine Levels Diptidase-1 (CNDP-1) In Cancer Kahexia Patients

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The Association Between the Administration of Ophiocephalus Striatus Extract to Carnosine Levels Diptidase-1 (CNDP-1) in Cancer Kahexia Patients

Introduction

Cancer kahexia, also known as anorexia-cachexia syndrome (ACS), is a metabolic disorder commonly found in patients with advanced-stage cancer. This condition is characterized by significant weight loss and loss of muscle mass, which can lead to poor health outcomes and reduced quality of life. Decreased carnosine levels diptidase-1 (CNDP-1) has been associated with poor health parameters in cancer kahexia patients. Carnosine is a dipeptide composed of the amino acids beta-alanine and histidine, which plays a crucial role in muscle function and metabolism. The administration of Ophiocephalus Striatus extract, a plant-based compound, has been shown to have potential therapeutic effects on various health conditions. This study aims to explore the effects of giving the Ophiocephalus Striatus extract to CNDP-1 levels in patients who experience cancer kahexia conditions.

Research Methods

This study was conducted on 30 cancer patients who met the inclusion criteria, through a clinical trial approach using the pre-post test method of one group. Measurement of carnosine levels dipeptidase-1 is carried out before and after administration of the Ophiocephalus Striatus extract. The study was conducted in all Hospitals of the Department of Disease in the Faculty of Medicine, University of North Sumatra, with the approval of the Research Ethics Commission of the Faculty of Medicine. The research activity took place from January to June 2019.

Research Result

Of the 30 respondents who participated, as many as 66.7% were men with an average age of 51.47 years. The most common types of cancer identified are gastrointestinal cancer (46.7%), followed by pulmonary carcinoma (20%), nasopharyngeal carcinoma (13.3%), and non-Hodgkin lymphoma (6.7%). The results of the analysis using the Wilcoxon test showed a significant relationship between carnosine levels dipeptidase-1 before and after giving the ophiocephalus striatus (p = 0.007) extract. This finding indicates an increase in carnosine levels dipeptidase-1 from 2.21 μg/ml before treatment to 2.8 μg/ml after treatment.

Discussion

The results of this study provide evidence that the Ophiocephalus Striatus extract can contribute positively in increasing CNDP-1 levels in cancer kahexia patients. The mechanism that underlies this increase in levels may be associated with nutritional and bioactive components contained in the extract, which can help reduce muscle breakdown and increase protein synthesis. Previous studies also show that treatment aimed at improving nutritional status can improve clinical outcomes in cancer patients, including their quality of life and prognosis.

The Role of Carnosine in Cancer Kahexia

Carnosine is a dipeptide that plays a crucial role in muscle function and metabolism. It has been shown to have antioxidant properties, which can help protect against oxidative stress and inflammation. In cancer kahexia patients, decreased carnosine levels have been associated with poor health parameters, including muscle wasting and weight loss. The administration of Ophiocephalus Striatus extract may help increase carnosine levels, which can lead to improved muscle function and metabolism.

The Potential of Ophiocephalus Striatus Extract as an Adjuvant Therapy

The results of this study highlight the potential of Ophiocephalus Striatus extract as an adjuvant therapy to support cancer treatment while improving the quality of life of patients. Previous studies have shown that nutritional interventions can improve clinical outcomes in cancer patients, including their quality of life and prognosis. The administration of Ophiocephalus Striatus extract may help reduce muscle breakdown and increase protein synthesis, which can lead to improved muscle function and metabolism.

Conclusion

Provision of ophiocephalus striatus extract shows a significant relationship with an increase in carnosine levels diptidase-1 in patients with cancer kahexia. This finding highlights the potential for the use of this extract as an adjuvant therapy to support cancer treatment while improving the quality of life of patients. More studies with larger research design and longer periods are needed to determine the long-term efficacy and safety of this therapy.

Recommendations

Based on the results of this study, the following recommendations are made:

  1. Further studies are needed to determine the long-term efficacy and safety of Ophiocephalus Striatus extract as an adjuvant therapy in cancer kahexia patients.
  2. The administration of Ophiocephalus Striatus extract should be considered as a potential treatment option for cancer kahexia patients.
  3. Further research is needed to explore the mechanisms underlying the increase in carnosine levels dipeptidase-1 after administration of Ophiocephalus Striatus extract.

Limitations of the Study

This study has several limitations, including:

  1. The small sample size of the study.
  2. The short duration of the study.
  3. The lack of control group in the study.

Future Directions

Future studies should aim to:

  1. Determine the long-term efficacy and safety of Ophiocephalus Striatus extract as an adjuvant therapy in cancer kahexia patients.
  2. Explore the mechanisms underlying the increase in carnosine levels dipeptidase-1 after administration of Ophiocephalus Striatus extract.
  3. Investigate the potential of Ophiocephalus Striatus extract as a treatment option for other health conditions.
    Frequently Asked Questions (FAQs) About the Association Between the Administration of Ophiocephalus Striatus Extract to Carnosine Levels Diptidase-1 (CNDP-1) in Cancer Kahexia Patients

Q: What is cancer kahexia?

A: Cancer kahexia, also known as anorexia-cachexia syndrome (ACS), is a metabolic disorder commonly found in patients with advanced-stage cancer. This condition is characterized by significant weight loss and loss of muscle mass, which can lead to poor health outcomes and reduced quality of life.

Q: What is the role of carnosine in cancer kahexia?

A: Carnosine is a dipeptide that plays a crucial role in muscle function and metabolism. It has been shown to have antioxidant properties, which can help protect against oxidative stress and inflammation. In cancer kahexia patients, decreased carnosine levels have been associated with poor health parameters, including muscle wasting and weight loss.

Q: What is Ophiocephalus Striatus extract?

A: Ophiocephalus Striatus extract is a plant-based compound that has been shown to have potential therapeutic effects on various health conditions. It is rich in nutritional and bioactive components that can help reduce muscle breakdown and increase protein synthesis.

Q: What are the potential benefits of Ophiocephalus Striatus extract in cancer kahexia patients?

A: The administration of Ophiocephalus Striatus extract may help increase carnosine levels, which can lead to improved muscle function and metabolism. This can result in improved clinical outcomes, including reduced muscle wasting and weight loss, and improved quality of life.

Q: What are the potential risks and side effects of Ophiocephalus Striatus extract?

A: While Ophiocephalus Striatus extract is generally considered safe, there may be potential risks and side effects associated with its use. These can include allergic reactions, gastrointestinal upset, and interactions with other medications.

Q: How can Ophiocephalus Striatus extract be administered?

A: Ophiocephalus Striatus extract can be administered orally in the form of capsules or tablets. The recommended dosage and administration schedule will depend on the specific product and individual patient needs.

Q: What are the potential interactions between Ophiocephalus Striatus extract and other medications?

A: Ophiocephalus Striatus extract may interact with other medications, including blood thinners, diabetes medications, and immunosuppressants. Patients should consult with their healthcare provider before taking Ophiocephalus Striatus extract if they are taking any other medications.

Q: Can Ophiocephalus Striatus extract be used in combination with other therapies?

A: Yes, Ophiocephalus Striatus extract can be used in combination with other therapies, including chemotherapy, radiation therapy, and nutritional interventions. Patients should consult with their healthcare provider to determine the best treatment plan for their individual needs.

Q: What are the potential long-term effects of Ophiocephalus Striatus extract?

A: The long-term effects of Ophiocephalus Striatus extract are not well understood and require further research. Patients should consult with their healthcare provider to determine the potential risks and benefits of long-term use.

Q: Where can I find more information about Ophiocephalus Striatus extract?

A: Patients can find more information about Ophiocephalus Striatus extract by consulting with their healthcare provider, searching online, or contacting a reputable healthcare organization or research institution.

Q: Is Ophiocephalus Striatus extract approved by regulatory agencies?

A: Ophiocephalus Striatus extract is not approved by regulatory agencies for the treatment of cancer kahexia. However, it may be available as a dietary supplement or investigational product. Patients should consult with their healthcare provider before taking Ophiocephalus Striatus extract.