Protection Activity Ethanol Extract Poguntano (picria Felt-terrae Lour.) Against Oxide Nitrite Levels And The Heart Histology Features Of Rat Induced
Introduction
Heart disease has become one of the serious complications that can occur due to the use of anticancer drugs such as doxyorubicin, which is included in the anthracline group. This drug often causes side effects in the form of cardiotoxicity, which is caused by an increase in levels of nitrite oxide (NO) in the body. Increased levels of this NO can cause myocardial dysfunction based on the apoptosis process. To overcome this problem, this study aims to evaluate the effects of ethanol extracts from Poguntano Herbs (Picria Fel-Terrae Lour.) Against the levels of NO in the plasma and the heart histology features of the doubsorubicin induced.
Background of the Study
The use of anticancer drugs such as doxyorubicin has become a common treatment for cancer patients. However, this drug often causes side effects in the form of cardiotoxicity, which can lead to heart disease. Cardiotoxicity is caused by an increase in levels of nitrite oxide (NO) in the body, which can cause myocardial dysfunction based on the apoptosis process. Apoptosis is a process of programmed cell death, which can lead to the death of heart cells and ultimately cause heart disease.
Methodology
In this study, the method used included observation of cardiac histology with the coloring of hematoxylin-eosin which was then analyzed under a microscope. In addition, no plasma levels are determined by spectrophotometry using Griess reagents. The results obtained show that in the negative control group, the NO levels have increased significantly (175.4 ± 1.25 μmol/L). Conversely, in the positive control group (47.4 ± 1.63 μmol/L) and groups that receive EEHP extracts at a dose of 50 mg (115.1 ± 0.95 μmol/L), 100 mg (103.8 ± 1, 56 μmol/L), 200 mg (94.2 ± 1.90 μmol/L), and 400 mg/kgBB (55.2 ± 1.54 μmol/L), there is a decrease in levels of no. This decrease shows the protective activity of the extract to the rat induced.
Results
The results of the histological examination of the rat's heart showed that there was no heart damage in the normal control group. Groups given positive extracts and controls show a better heart condition compared to negative control groups that receive documents, which indicate signs of bleeding and severe necrosis.
Discussion
Based on the analysis above, it can be concluded that the itanol extract of Poguntano herbs has a significant protective activity against oxide nitrite levels and improves the histological picture of the heart in the rat induced mice. This study opens the possibility for the development of herbal extract-based adjuvan therapy in reducing cardiotoxic side effects from chemotherapy therapy, especially those using doxyorubicin. Thus, this extract has the potential to be used as an alternative strategy in an effort to maintain the heart health of cancer patients undergoing treatment with doxyorubicin.
Conclusion
In conclusion, this study has shown that the ethanol extract of Poguntano herbs has a significant protective activity against oxide nitrite levels and improves the histological picture of the heart in the rat induced mice. This study opens the possibility for the development of herbal extract-based adjuvan therapy in reducing cardiotoxic side effects from chemotherapy therapy, especially those using doxyorubicin. Thus, this extract has the potential to be used as an alternative strategy in an effort to maintain the heart health of cancer patients undergoing treatment with doxyorubicin.
Recommendations
Based on the results of this study, it is recommended that further studies be conducted to evaluate the effects of the ethanol extract of Poguntano herbs in humans. Additionally, studies should be conducted to evaluate the safety and efficacy of the extract in reducing cardiotoxic side effects from chemotherapy therapy.
Limitations
This study has several limitations. Firstly, the study was conducted in rats, which may not be representative of humans. Secondly, the study only evaluated the effects of the ethanol extract of Poguntano herbs on oxide nitrite levels and heart histology features. Further studies should be conducted to evaluate the effects of the extract on other cardiotoxic side effects from chemotherapy therapy.
Future Directions
This study opens the possibility for the development of herbal extract-based adjuvan therapy in reducing cardiotoxic side effects from chemotherapy therapy, especially those using doxyorubicin. Further studies should be conducted to evaluate the effects of the ethanol extract of Poguntano herbs in humans and to evaluate the safety and efficacy of the extract in reducing cardiotoxic side effects from chemotherapy therapy.
Conclusion
In conclusion, this study has shown that the ethanol extract of Poguntano herbs has a significant protective activity against oxide nitrite levels and improves the histological picture of the heart in the rat induced mice. This study opens the possibility for the development of herbal extract-based adjuvan therapy in reducing cardiotoxic side effects from chemotherapy therapy, especially those using doxyorubicin. Thus, this extract has the potential to be used as an alternative strategy in an effort to maintain the heart health of cancer patients undergoing treatment with doxyorubicin.
Q: What is the purpose of this study?
A: The purpose of this study is to evaluate the effects of ethanol extracts from Poguntano Herbs (Picria Fel-Terrae Lour.) Against the levels of NO in the plasma and the heart histology features of the doubsorubicin induced.
Q: What is the significance of this study?
A: This study is significant because it opens the possibility for the development of herbal extract-based adjuvan therapy in reducing cardiotoxic side effects from chemotherapy therapy, especially those using doxyorubicin.
Q: What are the potential benefits of using Poguntano herbs as a treatment for cardiotoxicity?
A: The potential benefits of using Poguntano herbs as a treatment for cardiotoxicity include reducing the risk of heart disease, improving heart function, and reducing the risk of death from cardiotoxicity.
Q: How does Poguntano herbs work to reduce cardiotoxicity?
A: Poguntano herbs work to reduce cardiotoxicity by reducing the levels of nitrite oxide (NO) in the body, which can cause myocardial dysfunction based on the apoptosis process.
Q: What are the potential risks or side effects of using Poguntano herbs as a treatment for cardiotoxicity?
A: The potential risks or side effects of using Poguntano herbs as a treatment for cardiotoxicity are not well understood and may include allergic reactions, interactions with other medications, and unknown long-term effects.
Q: How can Poguntano herbs be used as a treatment for cardiotoxicity?
A: Poguntano herbs can be used as a treatment for cardiotoxicity by taking the ethanol extract of the herb orally, in a dose of 50-400 mg/kgBB, for a period of time as determined by the treating physician.
Q: What are the limitations of this study?
A: The limitations of this study include the use of rats as the study subjects, the limited number of study subjects, and the limited duration of the study.
Q: What are the future directions for this research?
A: The future directions for this research include conducting further studies in humans to evaluate the safety and efficacy of Poguntano herbs as a treatment for cardiotoxicity, and conducting studies to evaluate the effects of Poguntano herbs on other cardiotoxic side effects from chemotherapy therapy.
Q: How can readers learn more about this study and its findings?
A: Readers can learn more about this study and its findings by contacting the authors of the study, or by searching for the study on online databases such as PubMed or Google Scholar.
Q: What are the implications of this study for the treatment of cancer patients?
A: The implications of this study for the treatment of cancer patients are that Poguntano herbs may be a useful adjunct therapy to reduce the risk of cardiotoxicity associated with chemotherapy therapy, and may improve the quality of life for cancer patients undergoing treatment.
Q: What are the potential applications of this study in the field of oncology?
A: The potential applications of this study in the field of oncology include the development of herbal extract-based adjuvan therapy to reduce cardiotoxic side effects from chemotherapy therapy, and the use of Poguntano herbs as a treatment for cardiotoxicity in cancer patients.