Formulation And Evaluation Of Oral Dissolving Film (ODF) Preparations Using Ethanol Extracts Of Clove Leaves (Syzygium Aromaticum (L.) Merr. & Perry) As A Mouth Freshener
Overcoming Bad Breath with Oral Dissolving Films Based on Clove Leaf Extract
Bad breath or halitosis is a common problem caused by various factors such as poor oral hygiene, cavities, oral cavity infections, dry mouth, smoking, and food scraps left in the mouth. At present, the general method used to overcome halitosis is by brushing teeth, using mouthwash, and oral refreshing candy. However, Oral Dissolving Film (ODF) offers a practical and effective alternative as a mouth freshener. ODF is a thin, lightweight, and flexible film that dissolves easily in the mouth, making it an ideal solution for individuals who struggle with bad breath.
The advantage of ODF lies in its ease of use and its ability to release active substances quickly. Previous studies show the potential of clove leaf ethanol extract in inhibiting the growth of bacteria Streptococcus mutans, one of the main causes of bad breath. Clove leaves contain compounds such as tannins, saponins, alkaloids, triterpenoids, glycosides, and flavonoids which have antibacterial properties. This research aims to formulate and evaluate ODF preparations using clove leaf ethanol extract, test the stability and hedonic ODF, and determine ODF antibacterial activity against Streptococcus mutans.
The Method Used in This Study
Clove leaf ethanol extract is made by the method of maceration using 96% ethanol solvent. ODF is formulated by the Solvent Casting method and is divided into 5 formulas with variations in the concentration of gelatin and HPMC. The concentration of corn starch in each formula is 3%. ODF evaluation includes organoleptic tests, weight uniformity, thickness, pH, folding power, swelling, and water content. The stability test was carried out for 3 months at 25 ± 2 ° C and 40 ± 2 ° C. Antibacterial test on Streptococcus mutans is carried out by discus diffusion method on clove leaf extract and ODF. The hedonic test was carried out involving 20 respondents.
The Results of the Study Showed That
- The resulting ODF has the color, aroma, and distinctive taste of clove leaf extract.
- The weight of ODF ranges from 0.3450 to 0,1800 grams, thickness between 0.1480–0.2477 mm, pH between 6.06-6.33, the folding power of the film between 339.83–673.67 times, the ability to swelling good, and water content is less than 20%.
- ODF is stable for 3 months at a temperature of 25 ± 2 ° C and 40 ± 2 ° C.
- The five ODF formulas show antibacterial activity to Streptococcus mutans with a diameter of the inhibition zone between 8.6 mm to 9.1 mm.
- The hedonic test shows that the F2 formula (with a gelatin concentration of 0.75% and HPMC 2.25%) is most preferred with a score of 4 (like).
Conclusion
Clove leaf ethanol extract can be formulated into ODF which meets the requirements and is stable for 3 months at 25 ± 2 ° C and 40 ± 2 ° C. Formula F2 has physical characteristics, antibacterial activity, and the best level of preference. This study opens new opportunities in the development of oral refresher that is practical, effective, and easy to use. ODF based on clove leaf extract can be the right choice to overcome bad breath and maintain optimal oral health.
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Future Directions
The results of this study provide a promising foundation for the development of ODF based on clove leaf extract as a mouth freshener. Future studies can focus on:
- Scaling up the production of ODF to make it more commercially viable.
- Conducting clinical trials to evaluate the efficacy of ODF in reducing bad breath.
- Investigating the potential of ODF in treating other oral health issues, such as gum disease and tooth decay.
- Exploring the use of other natural extracts, such as peppermint or eucalyptus, in ODF formulations.
By continuing to research and develop ODF based on clove leaf extract, we can create a more effective and convenient solution for individuals struggling with bad breath.
Frequently Asked Questions
We've received many questions from readers about our recent study on the formulation and evaluation of Oral Dissolving Film (ODF) preparations using ethanol extracts of clove leaves as a mouth freshener. Here are some of the most frequently asked questions and our answers:
Q: What is Oral Dissolving Film (ODF)?
A: ODF is a thin, lightweight, and flexible film that dissolves easily in the mouth. It is a type of oral dosage form that is designed to release active substances quickly and easily.
Q: What is the purpose of using clove leaf ethanol extract in ODF?
A: Clove leaf ethanol extract has been shown to have antibacterial properties, which can help to inhibit the growth of bacteria that cause bad breath. By incorporating this extract into ODF, we can create a mouth freshener that is not only effective but also natural and safe.
Q: How was the clove leaf ethanol extract prepared?
A: The clove leaf ethanol extract was prepared using the method of maceration with 96% ethanol solvent. This process involves soaking the clove leaves in the solvent to extract the active compounds.
Q: What were the results of the ODF evaluation?
A: The ODF evaluation included organoleptic tests, weight uniformity, thickness, pH, folding power, swelling, and water content. The results showed that the ODF met the requirements and was stable for 3 months at 25 ± 2 ° C and 40 ± 2 ° C.
Q: Which ODF formula was most preferred by the respondents?
A: The hedonic test showed that the F2 formula (with a gelatin concentration of 0.75% and HPMC 2.25%) was most preferred by the respondents, with a score of 4 (like).
Q: What are the potential applications of ODF based on clove leaf extract?
A: ODF based on clove leaf extract can be used as a mouth freshener to overcome bad breath and maintain optimal oral health. It can also be used to treat other oral health issues, such as gum disease and tooth decay.
Q: What are the future directions for this research?
A: Future studies can focus on scaling up the production of ODF to make it more commercially viable, conducting clinical trials to evaluate the efficacy of ODF in reducing bad breath, and investigating the potential of ODF in treating other oral health issues.
Q: Can ODF be used by people with sensitive teeth or gums?
A: While ODF is generally safe and gentle, people with sensitive teeth or gums should consult with their dentist or healthcare provider before using ODF, especially if they have any underlying oral health conditions.
Q: How can I get more information about ODF based on clove leaf extract?
A: You can contact us directly or visit our website for more information about ODF based on clove leaf extract. We also recommend consulting with a healthcare professional or dentist for personalized advice on using ODF.
We hope this Q&A article has provided you with more information about our study on the formulation and evaluation of ODF preparations using ethanol extracts of clove leaves as a mouth freshener. If you have any further questions or concerns, please don't hesitate to contact us.