Formulation And Characterization Of Nanoemulgel Dosage Of Soybean Oil (Glycine Max L.)

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Introduction

Soybean oil, obtained from the seeds of the Glycine Max plant, is a source of vegetable oil that is rich in essential fatty acids and vitamin E, two important components that are beneficial for skin health. The latest innovation in the world of cosmetics is Nanoemulgel, a cosmetic delivery system designed to increase solubility of preparations thanks to a very small droplet size. Nanoemulgel is also known as the hydrogel-thickened nanoemulsion (HTN), where this system shows an increase in viscosity compared to ordinary nanoemulsions. The use of nanoemulgel in cosmetic products has gained significant attention in recent years due to its potential to improve the delivery and efficacy of active ingredients.

Research Purposes

This study aims to produce nanoemulgel preparations containing soybean oil with oil-in-water emulsion types and to evaluate the physical characterization of these preparations. The main objective of this study is to investigate the feasibility of using soybean oil as a key ingredient in nanoemulgel formulations and to evaluate the physical properties of these preparations. The results of this study will provide valuable information on the potential of soybean oil-based nanoemulgel preparations in the development of cosmetic products.

Methodology

Nanoemulgel preparation formulations are carried out with variations in the concentration of soybean oil, namely 3% (F1), 6% (F2), 9% (F3), 12% (F4), and 15% (F5). The manufacturing process uses spontaneous emulsification methods with the help of magnetic stirrer. Evaluation carried out includes organoleptic tests, homogeneity, pH, spread power, viscosity, particle size, and stability of the nanoemulgel preparation produced. The organoleptic tests were conducted to evaluate the appearance, texture, and smell of the nanoemulgel preparations. The homogeneity test was performed to evaluate the uniformity of the nanoemulgel preparations. The pH test was conducted to evaluate the pH level of the nanoemulgel preparations. The spread power test was performed to evaluate the ease of application of the nanoemulgel preparations. The viscosity test was conducted to evaluate the thickness of the nanoemulgel preparations. The particle size test was performed to evaluate the size of the particles in the nanoemulgel preparations. The stability test was conducted to evaluate the shelf life of the nanoemulgel preparations.

Results and Discussion

Nanoemulgel preparations that were successfully produced showed attractive characteristics, namely transparent yellow and have good homogeneity. PH preparations range from 5.93 to 6.48, which shows that this formulation is safe to use on the skin which generally has a pH of around 5.5. The scattered power measured reaches 4.3 to 6.9 cm, indicating that this preparation is easily applied and spread well on the surface of the skin. The resulting viscosity ranges from 2755 to 3667 cps, which shows that this nanoemulgel has a fairly thick consistency, ideal for cosmetic preparations. The measured globul size ranges from 69.18 to 752.52 Nm, indicating that this preparation contains particles in nano sizes that can increase penetration and effectiveness of active ingredients in it.

In addition, the stability test shows that nanoemulgel can last for 12 weeks at room temperature, high temperatures (using Climatic Chamber), and low temperatures (freezers). Only a few changes in the intensity of the color are observed, indicate that this formulation has good stability. The results of this study demonstrate that soybean oil can be successfully formulated into a nanoemulgel preparation type of oil emulsion in water. The physical characteristics of the nanoemulgel preparations, such as transparency, homogeneity, pH, spread power, viscosity, and particle size, are within the acceptable range for cosmetic products.

Conclusion

This study shows that soybean oil can be successfully formulated into a nanoemulgel preparation type of oil emulsion in water. Good physical characteristics and tested stability for 12 weeks make this preparation promising potential in the development of cosmetic products that are beneficial for the skin. This formulation not only provides benefits from soybean oil content but also utilizes nano technology to increase user effectiveness and comfort. The results of this study provide valuable information on the potential of soybean oil-based nanoemulgel preparations in the development of cosmetic products.

Future Directions

The results of this study demonstrate the potential of soybean oil-based nanoemulgel preparations in the development of cosmetic products. However, further studies are needed to evaluate the efficacy and safety of these preparations in human subjects. Additionally, the stability of the nanoemulgel preparations should be evaluated over a longer period of time to ensure that they remain effective and safe for use. The use of soybean oil-based nanoemulgel preparations in combination with other active ingredients should also be explored to enhance their efficacy and safety.

Limitations

This study has several limitations. The nanoemulgel preparations were only evaluated for their physical characteristics, and their efficacy and safety were not evaluated in human subjects. Additionally, the stability of the nanoemulgel preparations was only evaluated for 12 weeks, and their stability over a longer period of time is unknown. The use of soybean oil-based nanoemulgel preparations in combination with other active ingredients was not explored in this study.

Recommendations

Based on the results of this study, the following recommendations are made:

  1. Further studies should be conducted to evaluate the efficacy and safety of soybean oil-based nanoemulgel preparations in human subjects.
  2. The stability of the nanoemulgel preparations should be evaluated over a longer period of time to ensure that they remain effective and safe for use.
  3. The use of soybean oil-based nanoemulgel preparations in combination with other active ingredients should be explored to enhance their efficacy and safety.
  4. The physical characteristics of the nanoemulgel preparations should be evaluated in more detail to ensure that they meet the required standards for cosmetic products.

Conclusion

In conclusion, this study demonstrates the potential of soybean oil-based nanoemulgel preparations in the development of cosmetic products. The physical characteristics of the nanoemulgel preparations, such as transparency, homogeneity, pH, spread power, viscosity, and particle size, are within the acceptable range for cosmetic products. The stability of the nanoemulgel preparations is also good, and they can last for 12 weeks at room temperature, high temperatures, and low temperatures. Further studies are needed to evaluate the efficacy and safety of these preparations in human subjects and to explore their potential in combination with other active ingredients.

Introduction

In our previous article, we discussed the formulation and characterization of nanoemulgel dosage of soybean oil (Glycine max L.). In this article, we will answer some of the frequently asked questions related to this topic.

Q: What is nanoemulgel?

A: Nanoemulgel is a cosmetic delivery system designed to increase solubility of preparations thanks to a very small droplet size. It is also known as the hydrogel-thickened nanoemulsion (HTN), where this system shows an increase in viscosity compared to ordinary nanoemulsions.

Q: What are the benefits of using nanoemulgel in cosmetic products?

A: The use of nanoemulgel in cosmetic products has gained significant attention in recent years due to its potential to improve the delivery and efficacy of active ingredients. Nanoemulgel can increase the solubility of preparations, improve the stability of active ingredients, and enhance the skin penetration of active ingredients.

Q: What is the difference between nanoemulgel and ordinary emulsions?

A: The main difference between nanoemulgel and ordinary emulsions is the size of the droplets. Nanoemulgel has a very small droplet size, typically in the range of 10-100 nm, while ordinary emulsions have a larger droplet size, typically in the range of 1-10 μm.

Q: How is nanoemulgel prepared?

A: Nanoemulgel is prepared using a combination of surfactants, cosurfactants, and oils. The preparation process typically involves the use of a high-speed homogenizer or a microfluidizer to create the nano-sized droplets.

Q: What are the physical characteristics of nanoemulgel?

A: The physical characteristics of nanoemulgel include transparency, homogeneity, pH, spread power, viscosity, and particle size. These characteristics are typically evaluated using various techniques such as visual inspection, pH measurement, spread power measurement, viscosity measurement, and particle size analysis.

Q: How stable is nanoemulgel?

A: The stability of nanoemulgel is typically evaluated over a period of time, usually 12 weeks, at room temperature, high temperatures, and low temperatures. The results of this study demonstrate that nanoemulgel can last for 12 weeks at room temperature, high temperatures, and low temperatures.

Q: Can nanoemulgel be used in combination with other active ingredients?

A: Yes, nanoemulgel can be used in combination with other active ingredients to enhance their efficacy and safety. The use of nanoemulgel in combination with other active ingredients is an area of ongoing research and development.

Q: What are the potential applications of nanoemulgel in cosmetic products?

A: The potential applications of nanoemulgel in cosmetic products are vast and varied. Some of the potential applications include skin care products, hair care products, oral care products, and pharmaceutical products.

Q: What are the future directions for research and development of nanoemulgel?

A: The future directions for research and development of nanoemulgel include the evaluation of its efficacy and safety in human subjects, the exploration of its potential in combination with other active ingredients, and the development of new formulations and applications.

Conclusion

In conclusion, nanoemulgel is a promising cosmetic delivery system that has the potential to improve the delivery and efficacy of active ingredients in cosmetic products. The physical characteristics of nanoemulgel, such as transparency, homogeneity, pH, spread power, viscosity, and particle size, are within the acceptable range for cosmetic products. The stability of nanoemulgel is also good, and it can last for 12 weeks at room temperature, high temperatures, and low temperatures. Further studies are needed to evaluate the efficacy and safety of nanoemulgel in human subjects and to explore its potential in combination with other active ingredients.