Comparison Of The Estimated Value Of The Glomerular Filtration Rate Between Cystatin C And Creatinine In Chronic Chronic Kidney Disease

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Comparison of the Estimated Value of the Glomerular Filtration Rate between Cystatin C and Creatinine in Children with Chronic Kidney Disease

Introduction

Chronic kidney disease (CKD) is a growing global health concern, affecting millions of people worldwide. Early detection of kidney damage is crucial to prevent disease progression and improve the quality of life of patients. The glomerular filtration rate (GFR) or estimated GFR (eGFR) has become an essential marker for assessing kidney function and detecting kidney damage in the early stages. In this context, the choice of marker is critical, and this article aims to compare the estimated value of the glomerular filtration rate between cystatin C and creatinine in children with CKD.

Background

Cystatin C is a protein produced by all body cells and is filtered by the kidneys. It is considered a better marker for eGFR than creatinine due to several advantages. Firstly, cystatin C is not influenced by muscle mass, unlike creatinine, which can lead to different values in individuals with varying muscle mass, even if their kidney function is the same. Secondly, cystatin C is more sensitive in detecting kidney damage in the early stages compared to creatinine. Finally, cystatin C is not influenced by diet, whereas creatinine values can be affected by protein intake.

Methodology

This study aimed to compare the eGFR values obtained from creatinine and cystatin C in children with CKD. The study involved 36 children with CKD treated at Adam Malik Hajj Hospital, Medan, during the period January 2016 to March 2016. Blood samples were taken to determine the value of creatinine and cystatin C, and then the eGFR calculation was carried out using the CKD-EPI equations. Other factors considered in this study were the gender, age, height, and weight of the child.

Results

The results of the study showed a significant difference between eGFR based on creatinine and cystatin C (Mean Difference 36.8, 95% CI 29.0 - 44.9, P = 0.001). This indicates that cystatin C can provide more accurate estimated eGFR compared to creatinine in children with CKD. Furthermore, the proportion of children with normal eGFR and decreased eGFR based on creatinine and cystatin C showed a significant difference (p = 0.001). This suggests that cystatin C can be better in detecting kidney damage compared to creatinine.

Discussion

The findings of this study are consistent with previous research, which has shown that cystatin C is a more accurate marker for eGFR than creatinine. The results of this study highlight the importance of using cystatin C as a marker for eGFR in children with CKD. The study also found that gender, age, height, and weight do not have a significant relationship with the difference in eGFR based on creatinine and cystatin C.

Conclusion

In conclusion, this study shows that cystatin C is more accurate in estimating eGFR in children with CKD compared to creatinine, especially in the early stages of the disease. Cystatin C can be a better marker to monitor the development of CKD in children and can help in making more appropriate clinical decisions.

Recommendations

  • Further research needs to be done to examine the role of cystatin C in CKD monitoring in children and its effectiveness in increasing treatment results.
  • It is necessary to do socialization and education to health workers regarding the use of cystatin C as an eGFR marker in children with CKD.

Limitations

  • This research is only conducted on children with CKD and the results may not be generalized to other populations.
  • Further research needs to be done to determine the optimal role of cystatin C in CKD management in children.

Future Directions

The findings of this study have significant implications for the management of CKD in children. Further research is needed to explore the role of cystatin C in CKD monitoring and its effectiveness in increasing treatment results. Additionally, socialization and education to health workers regarding the use of cystatin C as an eGFR marker in children with CKD are essential to improve the quality of care for these patients.

References

  • [List of references cited in the study]

Appendix

  • [Additional information or data that may be of interest to the reader]

Abstract

This study aimed to compare the estimated value of the glomerular filtration rate between cystatin C and creatinine in children with chronic kidney disease. The results showed a significant difference between eGFR based on creatinine and cystatin C, indicating that cystatin C can provide more accurate estimated eGFR compared to creatinine in children with CKD. The study highlights the importance of using cystatin C as a marker for eGFR in children with CKD and recommends further research to explore its role in CKD monitoring and its effectiveness in increasing treatment results.
Frequently Asked Questions (FAQs) about the Estimated Value of the Glomerular Filtration Rate between Cystatin C and Creatinine in Children with Chronic Kidney Disease

Q: What is the glomerular filtration rate (GFR) and why is it important?

A: The GFR is a measure of the kidneys' ability to filter waste and excess fluids from the blood. It is an essential marker for assessing kidney function and detecting kidney damage in the early stages. A low GFR indicates kidney damage or disease.

Q: What is the difference between cystatin C and creatinine as markers for GFR?

A: Cystatin C is a protein produced by all body cells and is filtered by the kidneys. It is considered a better marker for GFR than creatinine due to several advantages, including not being influenced by muscle mass, being more sensitive in detecting kidney damage, and not being influenced by diet.

Q: Why is cystatin C a better marker for GFR than creatinine?

A: Cystatin C is a more accurate marker for GFR than creatinine because it is not influenced by muscle mass, making it a more reliable measure of kidney function. Additionally, cystatin C is more sensitive in detecting kidney damage, making it a better marker for early detection of kidney problems.

Q: What are the implications of using cystatin C as a marker for GFR in children with chronic kidney disease?

A: The use of cystatin C as a marker for GFR in children with chronic kidney disease can lead to more accurate diagnosis and treatment of kidney damage. It can also help in making more informed clinical decisions and improving the quality of care for these patients.

Q: What are the limitations of this study?

A: This study is only conducted on children with chronic kidney disease and the results may not be generalized to other populations. Further research is needed to determine the optimal role of cystatin C in chronic kidney disease management in children.

Q: What are the future directions for research on cystatin C as a marker for GFR in children with chronic kidney disease?

A: Further research is needed to explore the role of cystatin C in chronic kidney disease monitoring and its effectiveness in increasing treatment results. Additionally, socialization and education to health workers regarding the use of cystatin C as an GFR marker in children with chronic kidney disease are essential to improve the quality of care for these patients.

Q: How can cystatin C be used in clinical practice to improve the management of chronic kidney disease in children?

A: Cystatin C can be used as a marker for GFR in children with chronic kidney disease to improve the accuracy of diagnosis and treatment. It can also be used to monitor the progression of kidney damage and to make more informed clinical decisions.

Q: What are the potential benefits of using cystatin C as a marker for GFR in children with chronic kidney disease?

A: The use of cystatin C as a marker for GFR in children with chronic kidney disease can lead to more accurate diagnosis and treatment of kidney damage, improved quality of care, and better outcomes for these patients.

Q: What are the potential risks or limitations of using cystatin C as a marker for GFR in children with chronic kidney disease?

A: The use of cystatin C as a marker for GFR in children with chronic kidney disease may be limited by the availability of cystatin C assays and the need for further research to determine the optimal role of cystatin C in chronic kidney disease management in children.

Q: How can healthcare providers and researchers work together to improve the management of chronic kidney disease in children?

A: Healthcare providers and researchers can work together to improve the management of chronic kidney disease in children by sharing knowledge and expertise, conducting further research, and implementing evidence-based practices in clinical settings.