Comparison Of The Effects Of The Therapy Of Fluticasone Furoate Nasal Spray And Oral Methylprednisolone In Nasal Polyps Is Assessed By Changes In The Number Of Inflammatory Cells And Nasal Polyps Stage

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Comparison of the Effectiveness of Fluticasone Furoate Nasal Spray and Oral Methylprednisolone in Nasal Polyps

Introduction

Nasal polyps are a chronic inflammatory disease that affects the nasal cavity and sinuses, caused by various predisposing and pathogenesis factors. Corticosteroids are the primary treatment for nasal polyps due to their effectiveness in reducing inflammation and shrinking the size of polyps. The mechanism of action is to induce apoptosis in inflammatory cells. Corticosteroids of nasal spray have lipophilic properties, making it easy to penetrate cell membranes and bind to glucocorticoid receptors in the respiratory tract.

Objective

This study aims to compare the effectiveness of the therapy of Fluticasone Furoate (FF) nasal spray with oral methylprednisolone in patients with nasal polyps based on changes in the number of inflammatory cells (neutrophils, eosinophils, lymphocytes, and plasma cells) and plasma stages. Understanding the effectiveness of these treatments is crucial in determining the best course of action for patients with nasal polyps.

Method

This study involved 30 nasal polyps patients who were biopsy and treated at H. Adam Malik Hospital in the period of January 2013 to June 2014. Patients were divided into two groups: 16 patients received nasal ff therapy and 14 patients received oral methylprednisolone therapy. Changes in the number of inflammatory cells are calculated using haematoxylin eosin coloring under a microscope. Histopathology Classification of polyps based on the classification of Hellquist (1996) and determining the stadium based on Lund and Mackay (1995). Data were analyzed and tested statistics using T-Test with a maximum level of 5%.

Results

Of the 30 patients, 63.33% are male and the majority aged ≥ 40 years (66.67%). The most commonly found stage of polyps is stage two. Neutrophilic polyps dominate (60%), while eosinophilic polyps are 40%. Nasal spray ff therapy shows a significant decrease in the number of neutrophils, lymphocytes, and plasma cells, but not in eosinophils. Polyps stage also experienced a significant decrease after therapy. In groups treated by oral methylprednisolone, all inflammatory cells have decreased significantly and the stage of polyps also decreased significantly.

The results of statistical analysis show that there is no significant difference in the decline in the number of inflammatory cells and the stage of polyps between the two groups of patients. This suggests that both treatments are effective in reducing inflammation and shrinking the size of polyps.

Conclusion

This study shows that there is no significant difference in the effectiveness of the therapy of nasal ff and oral methylprednisolone ff in patients with nasal polyps based on changes in the number of inflammatory cells and stage polyps. Both treatments have their advantages and disadvantages, and the choice of treatment depends on individual patient needs.

Additional Analysis and Explanation

The results of this study indicate that both the nasal and methylprednisolone oral ff are effective in reducing inflammation and shrinking the size of the polyps. This shows that the two therapies have a similar work mechanism, namely by inducing apoptosis in inflammatory cells. Although there is no significant difference in the effectiveness between the two therapies, the use of nasal spray ff has several advantages, namely:

Easier Administration: FF Nose spray is easier and practical to use compared to oral methylprednisolone that must be drunk. Lower side effects: Nasal spray ff has a lower systemic side effect of side effects compared to oral methylprednisolone.

Therefore, the nasal spray ff can be a better therapeutic choice for nasal polyps patients who want practical treatment with a lower systemic side effect.

Recommendation

Further research with a more complex design and larger samples is needed to confirm the results of this study and to study the effectiveness of long-term therapy. Understanding the long-term effects of these treatments is crucial in determining the best course of action for patients with nasal polyps.

Keywords: Nasal polyps, fluticasone furoate, methylprednisolone, inflammatory cells, stadium polyps, effectiveness of therapy.

Limitations of the Study

This study has several limitations, including:

  • The sample size is relatively small, which may not be representative of the general population.
  • The study only included patients with nasal polyps, and the results may not be applicable to other conditions.
  • The study only compared two treatments, and the results may not be generalizable to other treatments.

Future Directions

Future studies should aim to:

  • Increase the sample size to improve the representativeness of the results.
  • Include patients with other conditions to improve the generalizability of the results.
  • Compare multiple treatments to determine the most effective treatment for nasal polyps.

Conclusion

In conclusion, this study shows that there is no significant difference in the effectiveness of the therapy of nasal ff and oral methylprednisolone ff in patients with nasal polyps based on changes in the number of inflammatory cells and stage polyps. Both treatments have their advantages and disadvantages, and the choice of treatment depends on individual patient needs. Further research is needed to confirm the results of this study and to study the effectiveness of long-term therapy.
Frequently Asked Questions (FAQs) about Nasal Polyps and Treatment Options

Q: What are nasal polyps?

A: Nasal polyps are growths that occur on the lining of the nasal passages and sinuses. They are usually soft and painless, but can cause symptoms such as congestion, loss of smell, and difficulty breathing.

Q: What causes nasal polyps?

A: The exact cause of nasal polyps is not known, but they are often associated with chronic inflammation and allergies. Other factors that may contribute to the development of nasal polyps include asthma, sinus infections, and genetic predisposition.

Q: What are the symptoms of nasal polyps?

A: The symptoms of nasal polyps can vary depending on the size and location of the polyps, but common symptoms include:

  • Congestion and stuffiness
  • Loss of smell
  • Difficulty breathing through the nose
  • Postnasal drip
  • Coughing
  • Sinus pressure and pain

Q: What are the treatment options for nasal polyps?

A: The treatment options for nasal polyps depend on the size and location of the polyps, as well as the severity of symptoms. Common treatment options include:

  • Nasal corticosteroids: These medications can help reduce inflammation and shrink the size of the polyps.
  • Oral corticosteroids: These medications can help reduce inflammation and swelling in the nasal passages and sinuses.
  • Surgery: In some cases, surgery may be necessary to remove the polyps.
  • Endoscopic sinus surgery: This is a minimally invasive procedure that uses a flexible tube with a camera and light on the end to remove the polyps.

Q: What is Fluticasone Furoate (FF) nasal spray?

A: Fluticasone Furoate (FF) nasal spray is a type of nasal corticosteroid that is used to treat nasal polyps. It works by reducing inflammation and swelling in the nasal passages and sinuses, which can help shrink the size of the polyps.

Q: What are the benefits of using Fluticasone Furoate (FF) nasal spray?

A: The benefits of using Fluticasone Furoate (FF) nasal spray include:

  • Reduced inflammation and swelling in the nasal passages and sinuses
  • Shrinkage of the size of the polyps
  • Improved symptoms such as congestion and loss of smell
  • Easy to use and administer

Q: What are the potential side effects of Fluticasone Furoate (FF) nasal spray?

A: The potential side effects of Fluticasone Furoate (FF) nasal spray include:

  • Nasal irritation and dryness
  • Headache
  • Coughing
  • Sinus pressure and pain

Q: Is Fluticasone Furoate (FF) nasal spray effective in treating nasal polyps?

A: Yes, Fluticasone Furoate (FF) nasal spray has been shown to be effective in treating nasal polyps by reducing inflammation and swelling in the nasal passages and sinuses, and shrinking the size of the polyps.

Q: Can Fluticasone Furoate (FF) nasal spray be used in combination with other treatments?

A: Yes, Fluticasone Furoate (FF) nasal spray can be used in combination with other treatments such as oral corticosteroids and surgery to treat nasal polyps.

Q: How long does it take to see the effects of Fluticasone Furoate (FF) nasal spray?

A: The effects of Fluticasone Furoate (FF) nasal spray can be seen within a few days to a week after starting treatment.

Q: Can Fluticasone Furoate (FF) nasal spray be used in children?

A: Yes, Fluticasone Furoate (FF) nasal spray can be used in children, but it should be used under the guidance of a healthcare professional.

Q: Can Fluticasone Furoate (FF) nasal spray be used in pregnant or breastfeeding women?

A: Yes, Fluticasone Furoate (FF) nasal spray can be used in pregnant or breastfeeding women, but it should be used under the guidance of a healthcare professional.

Q: What are the potential interactions between Fluticasone Furoate (FF) nasal spray and other medications?

A: The potential interactions between Fluticasone Furoate (FF) nasal spray and other medications include:

  • Increased risk of side effects such as nasal irritation and dryness
  • Reduced effectiveness of other medications such as oral corticosteroids

Q: How should Fluticasone Furoate (FF) nasal spray be stored?

A: Fluticasone Furoate (FF) nasal spray should be stored in a cool, dry place, away from direct sunlight and heat.

Q: How long does Fluticasone Furoate (FF) nasal spray last?

A: Fluticasone Furoate (FF) nasal spray typically lasts for 6-12 months after opening.

Q: Can Fluticasone Furoate (FF) nasal spray be used in patients with allergies?

A: Yes, Fluticasone Furoate (FF) nasal spray can be used in patients with allergies, but it should be used under the guidance of a healthcare professional.

Q: Can Fluticasone Furoate (FF) nasal spray be used in patients with asthma?

A: Yes, Fluticasone Furoate (FF) nasal spray can be used in patients with asthma, but it should be used under the guidance of a healthcare professional.

Q: What are the potential risks of using Fluticasone Furoate (FF) nasal spray?

A: The potential risks of using Fluticasone Furoate (FF) nasal spray include:

  • Increased risk of side effects such as nasal irritation and dryness
  • Reduced effectiveness of other medications such as oral corticosteroids
  • Potential for long-term effects such as adrenal suppression

Q: How can I get more information about Fluticasone Furoate (FF) nasal spray?

A: You can get more information about Fluticasone Furoate (FF) nasal spray by talking to your healthcare professional or by visiting the manufacturer's website.