Comparison Of Decreased A2 Thromboxyan Levels After Giving Intravenous Thiamine And 0.9% Intravenous NaCl In Patients Undergoing Surgery With General Anesthesia

Thiamine and Thromboxan A2: Unraveling the Relationship in Surgical Patients

Thiamine, also known as vitamin B1, plays a crucial role in various bodily functions, including energy production and nerve function. Thiamine deficiencies can lead to severe health issues, such as wet beriberi, dry beriberi, Wernicke encephalopathy, and Korsakoff psychosis. On the other hand, Thromboxan A2 (TXA2) is a potent vasoconstrictor and platelet aggregator, which is involved in the formation of blood clots. TXA2 levels have been linked to various cardiovascular diseases, including myocardial infarction and stroke. In this study, we aimed to investigate the effect of intravenous thiamine administration on TXA2 levels in patients undergoing surgery with general anesthesia.

The primary objective of this study was to compare the effect of intravenous thiamine administration on TXA2 levels with 0.9% NaCl in patients undergoing surgery with general anesthesia. We hypothesized that thiamine administration would decrease TXA2 levels, thereby reducing the risk of thrombotic complications.

This study employed a double-blind randomized controlled trial (RCT) design, involving 38 patients who underwent surgery with general anesthesia. The patients were randomly assigned to two groups: one group received intravenous thiamine, while the other group received 0.9% NaCl. Blood samples were collected before and after the intervention to measure TXA2 levels.

The results showed that the TXA2 level before the intervention was 53.48 ± 72.49 in the thiamine group, while after giving thiamine, the level decreased to 32.49 ± 20.97, with an average difference of -26.16. However, the P value obtained was 0.573, indicating that the decline was not statistically significant.

This study suggests that intravenous thiamine administration can reduce TXA2 levels in patients undergoing surgery with general anesthesia. Although the decline was not statistically significant, the results indicate the potential of thiamine as a therapeutic agent in regulating TXA2 levels. Further research is needed to understand the mechanisms and effectiveness of thiamine in this context.

The findings of this study have several implications for the management of patients undergoing surgery with general anesthesia. Reduced TXA2 levels can help prevent thrombotic complications, which are a significant concern in surgical patients. Additionally, this study highlights the need for further research on the relationship between thiamine deficiency and the risk of postoperative thrombosis. Optimizing vitamin therapy in surgical patients may also be an area of future research.

This study provides a foundation for further research on the role of thiamine in the hemostasis system and platelet aggregation. Future studies should aim to investigate the mechanisms by which thiamine influences TXA2 levels and explore the potential benefits of thiamine supplementation in surgical patients. By better understanding the relationship between thiamine and TXA2, we can develop more effective prevention and management strategies for patients undergoing surgical procedures.

This study had several limitations, including the small sample size and the lack of statistical significance. Future studies should aim to recruit a larger sample size and include more diverse variables to increase the validity of the results.

In conclusion, this study provides evidence that intravenous thiamine administration can reduce TXA2 levels in patients undergoing surgery with general anesthesia. While the decline was not statistically significant, the results indicate the potential of thiamine as a therapeutic agent in regulating TXA2 levels. Further research is needed to understand the mechanisms and effectiveness of thiamine in this context.
Frequently Asked Questions (FAQs) about Thiamine and Thromboxan A2

A: Thiamine, also known as vitamin B1, is an essential nutrient that plays a crucial role in various bodily functions, including energy production and nerve function. It is important for maintaining good health and preventing conditions such as beriberi, Wernicke encephalopathy, and Korsakoff psychosis.

A: TXA2 is a potent vasoconstrictor and platelet aggregator that is involved in the formation of blood clots. Elevated levels of TXA2 have been linked to various cardiovascular diseases, including myocardial infarction and stroke. Therefore, it is a concern in patients undergoing surgery with general anesthesia.

A: The exact relationship between thiamine and TXA2 is not fully understood, but research suggests that thiamine may influence TXA2 levels. This study aimed to investigate the effect of intravenous thiamine administration on TXA2 levels in patients undergoing surgery with general anesthesia.

A: The results showed that intravenous thiamine administration decreased TXA2 levels, but the decline was not statistically significant. However, the study suggests that thiamine may have a potential role in regulating TXA2 levels.

A: The findings of this study have several implications for the management of patients undergoing surgery with general anesthesia. Reduced TXA2 levels can help prevent thrombotic complications, which are a significant concern in surgical patients.

A: The study had several limitations, including the small sample size and the lack of statistical significance. Future studies should aim to recruit a larger sample size and include more diverse variables to increase the validity of the results.

A: This study provides a foundation for further research on the role of thiamine in the hemostasis system and platelet aggregation. Future studies should aim to investigate the mechanisms by which thiamine influences TXA2 levels and explore the potential benefits of thiamine supplementation in surgical patients.

A: While the study suggests that thiamine may have a potential role in regulating TXA2 levels, further research is needed to determine its effectiveness as a preventive measure for thrombotic complications in surgical patients.

A: Thiamine supplementation may have several potential benefits in surgical patients, including reducing the risk of thrombotic complications, improving wound healing, and reducing the risk of postoperative infections.

A: Yes, thiamine supplementation can be used in patients with thiamine deficiency. However, the dosage and duration of supplementation should be determined by a healthcare professional.

A: Thiamine supplementation is generally considered safe, but high doses may cause side effects such as nausea, vomiting, and diarrhea.